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TitleThe [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport.
Journal, issue, pagesScience, Vol. 355, Year 2017
Publish dateSep 15, 2015 (structure data deposition date)
AuthorsO'Brien, E. / Holt, M.E. / Thompson, M.K. / Salay, L.E. / Ehlinger, A.C. / Chazin, W.J. / Barton, J.K.
External linksScience / PubMed:28232525
MethodsX-ray diffraction
Resolution1.93 - 2.3 Å
Structure data

PDB-5dqo:
Crystal structure of Y347F mutant of human primase p58 iron-sulfur cluster domain
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-5i7m:
Crystal structure of Y345F mutant of human primase p58 iron-sulfur cluster domain
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

Chemicals

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsREPLICATION / Iron-Sulfur Cluster / DNA Priming / DNA replication / primase / [4Fe-4S] / p58C

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