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Structure paper

TitleMHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 24, Page 387-394, Year 2017
Publish dateSep 1, 2016 (structure data deposition date)
AuthorsPymm, P. / Illing, P.T. / Ramarathinam, S.H. / O'Connor, G.M. / Hughes, V.A. / Hitchen, C. / Price, D.A. / Ho, B.K. / McVicar, D.W. / Brooks, A.G. ...Pymm, P. / Illing, P.T. / Ramarathinam, S.H. / O'Connor, G.M. / Hughes, V.A. / Hitchen, C. / Price, D.A. / Ho, B.K. / McVicar, D.W. / Brooks, A.G. / Purcell, A.W. / Rossjohn, J. / Vivian, J.P.
External linksNat. Struct. Mol. Biol. / PubMed:28218747
MethodsX-ray diffraction
Resolution1.686 - 2.1 Å
Structure data

PDB-5t6w:
HLA-B*57:01 presenting SSTRGISQLW
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-5t6x:
HLA-B*57:01 presenting TSTTSVASSW
Method: X-RAY DIFFRACTION / Resolution: 1.686 Å

PDB-5t6y:
HLA-B*57:01 presenting TSTFEDVKILAF
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

PDB-5t6z:
KIR3DL1 in complex with HLA-B*57:01-TW10
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5t70:
KIR3DL1 in complex with HLA-B*57:01 presenting TSNLQEQIGW
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / human leukocyte antigen Immunoglobulin domain antigen presentation

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