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Structure paper

TitlePotent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Journal, issue, pagesNat Commun, Vol. 8, Page 14158-14158, Year 2017
Publish dateOct 17, 2016 (structure data deposition date)
AuthorsRossey, I. / Gilman, M.S. / Kabeche, S.C. / Sedeyn, K. / Wrapp, D. / Kanekiyo, M. / Chen, M. / Mas, V. / Spitaels, J. / Melero, J.A. ...Rossey, I. / Gilman, M.S. / Kabeche, S.C. / Sedeyn, K. / Wrapp, D. / Kanekiyo, M. / Chen, M. / Mas, V. / Spitaels, J. / Melero, J.A. / Graham, B.S. / Schepens, B. / McLellan, J.S. / Saelens, X.
External linksNat Commun / PubMed:28194013
MethodsX-ray diffraction
Resolution1.874 - 3.8 Å
Structure data

PDB-5toj:
Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-5tok:
Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66
Method: X-RAY DIFFRACTION / Resolution: 3.8 Å

PDB-5tp3:
Crystal structure of the RSV-neutralizing single-domain antibody F-VHH-4
Method: X-RAY DIFFRACTION / Resolution: 1.874 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • human respiratory syncytial virus
  • lama glama (llama)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Fusion / nanobody / immunoglobulin fold / complex / VIRAL PROTEIN-IMMUNE SYSTEM complex / IMMUNE SYSTEM / respiratory syncytial virus / Ig fold / fusion glycoprotein / pseudomerohedral

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