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TitleThieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
Journal, issue, pagesJ. Med. Chem., Vol. 60, Page 1673-1692, Year 2017
Publish dateJul 7, 2016 (structure data deposition date)
AuthorsSartori, L. / Mercurio, C. / Amigoni, F. / Cappa, A. / Faga, G. / Fattori, R. / Legnaghi, E. / Ciossani, G. / Mattevi, A. / Meroni, G. ...Sartori, L. / Mercurio, C. / Amigoni, F. / Cappa, A. / Faga, G. / Fattori, R. / Legnaghi, E. / Ciossani, G. / Mattevi, A. / Meroni, G. / Moretti, L. / Cecatiello, V. / Pasqualato, S. / Romussi, A. / Thaler, F. / Trifiro, P. / Villa, M. / Vultaggio, S. / Botrugno, O.A. / Dessanti, P. / Minucci, S. / Zagarri, E. / Carettoni, D. / Iuzzolino, L. / Varasi, M. / Vianello, P.
External linksJ. Med. Chem. / PubMed:28186755
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-5lgn:
Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 19
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-6W0:
~{N}-[3-(methoxymethyl)phenyl]-4-methyl-thieno[3,2-b]pyrrole-5-carboxamide

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE

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