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Structure paper

TitleDecoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures.
Journal, issue, pagesCurr Mol Pharmacol, Vol. 10, Page 334-344, Year 2017
Publish dateApr 10, 2015 (structure data deposition date)
AuthorsDore, A.S. / Bortolato, A. / Hollenstein, K. / Cheng, R.K.Y. / Read, R.J. / Marshall, F.H.
External linksCurr Mol Pharmacol / PubMed:28183242
MethodsX-ray diffraction
Resolution3.183 Å
Structure data

PDB-4z9g:
Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry
Method: X-RAY DIFFRACTION / Resolution: 3.183 Å

Chemicals

ChemComp-OLA:
OLEIC ACID

ChemComp-1Q5:
3,6-dimethyl-N-(pentan-3-yl)-2-(2,4,6-trimethylphenoxy)pyridin-4-amine

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • enterobacteria phage rb51 (virus)
KeywordsSIGNALING PROTEIN / 7TM / GPCR / FAMILY B / G-PROTEIN / MEMBRANE / MEMBRANE PROTEIN / RECEPTOR / tNCS / HEXAGONAL

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