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TitleSpider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7.
Journal, issue, pagesBiochim. Biophys. Acta, Vol. 1859, Page 835-844, Year 2017
Publish dateOct 11, 2016 (structure data deposition date)
AuthorsAgwa, A.J. / Lawrence, N. / Deplazes, E. / Cheneval, O. / Chen, R.M. / Craik, D.J. / Schroeder, C.I. / Henriques, S.T.
External linksBiochim. Biophys. Acta / PubMed:28115115
MethodsNMR (solution)
Structure data

PDB-5tlr:
Solution NMR structure of gHwTx-IV
Method: SOLUTION NMR

Source
  • haplopelma schmidti (Chinese earth tiger)
KeywordsTOXIN / spider toxin / disulfide-rich / sodium channel inhibitor

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