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TitleCovalent Guanosine Mimetic Inhibitors of G12C KRAS.
Journal, issue, pagesACS Med Chem Lett, Vol. 8, Page 61-66, Year 2017
Publish dateJul 21, 2016 (structure data deposition date)
AuthorsXiong, Y. / Lu, J. / Hunter, J. / Li, L. / Scott, D. / Choi, H.G. / Lim, S.M. / Manandhar, A. / Gondi, S. / Sim, T. ...Xiong, Y. / Lu, J. / Hunter, J. / Li, L. / Scott, D. / Choi, H.G. / Lim, S.M. / Manandhar, A. / Gondi, S. / Sim, T. / Westover, K.D. / Gray, N.S.
External linksACS Med Chem Lett / PubMed:28105276
MethodsX-ray diffraction
Resolution2.702 Å
Structure data

PDB-5kyk:
Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs
Method: X-RAY DIFFRACTION / Resolution: 2.702 Å

Chemicals

ChemComp-6ZD:
5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE inhibitor / KRAS / Cancer / covalent inhibitor / HYDROLASE-HYDROLASE inhibitor complex

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