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| Title | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 60, Page 2215-2226, Year 2017 |
| Publish date | Oct 14, 2016 (structure data deposition date) |
 Authors | Huang, Y. / Zhang, J. / Yu, Z. / Zhang, H. / Wang, Y. / Lingel, A. / Qi, W. / Gu, J. / Zhao, K. / Shultz, M.D. ...Huang, Y. / Zhang, J. / Yu, Z. / Zhang, H. / Wang, Y. / Lingel, A. / Qi, W. / Gu, J. / Zhao, K. / Shultz, M.D. / Wang, L. / Fu, X. / Sun, Y. / Zhang, Q. / Jiang, X. / Zhang, C. / Li, L. / Zeng, J. / Feng, L. / Liu, Y. / Zhang, M. / Zhang, L. / Zhao, M. / Gao, Z. / Liu, X. / Fang, D. / Guo, H. / Mi, Y. / Gabriel, T. / Dillon, M.P. / Atadja, P. / Oyang, C. |
 External links | J. Med. Chem. / PubMed:28092155 |
| Methods | X-ray diffraction |
| Resolution | 2.5 - 2.88 Å |
| Structure data |  PDB-5h24:  PDB-5h25: |
| Chemicals |  ChemComp-LQG:  ChemComp-HOH:  ChemComp-LQH: |
| Source |
|
 Keywords | Transferase/Transferase Inhibitor / EED / PRC2 / inhibitor / Transferase-Transferase Inhibitor complex |
homo sapiens (human)