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Title | Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 1060-1075, Year 2017 |
Publish date | Oct 7, 2016 (structure data deposition date) |
![]() | Corte, J.R. / Fang, T. / Osuna, H. / Pinto, D.J. / Rossi, K.A. / Myers, J.E. / Sheriff, S. / Lou, Z. / Zheng, J.J. / Harper, T.W. ...Corte, J.R. / Fang, T. / Osuna, H. / Pinto, D.J. / Rossi, K.A. / Myers, J.E. / Sheriff, S. / Lou, Z. / Zheng, J.J. / Harper, T.W. / Bozarth, J.M. / Wu, Y. / Luettgen, J.M. / Seiffert, D.A. / Decicco, C.P. / Wexler, R.R. / Quan, M.L. |
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Methods | X-ray diffraction |
Resolution | 1.55 - 2.12 Å |
Structure data | ![]() PDB-5tks: ![]() PDB-5tkt: ![]() PDB-5tku: |
Chemicals | ![]() ChemComp-7DL: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-7DS: ![]() ChemComp-7DK: |
Source |
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![]() | hydrolase/hydrolase inhibitor / HYDROLASE / SERINE PROTEASE / BLOOD COAGULATION FACTOR / PROTEIN INHIBITOR COMPLEX / hydrolase-hydrolase inhibitor complex |