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Structure paper

TitleStructure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 27, Page 1099-1104, Year 2017
Publish dateSep 13, 2016 (structure data deposition date)
AuthorsKeung, W. / Boloor, A. / Brown, J. / Kiryanov, A. / Gangloff, A. / Lawson, J.D. / Skene, R. / Hoffman, I. / Atienza, J. / Kahana, J. ...Keung, W. / Boloor, A. / Brown, J. / Kiryanov, A. / Gangloff, A. / Lawson, J.D. / Skene, R. / Hoffman, I. / Atienza, J. / Kahana, J. / De Jong, R. / Farrell, P. / Balakrishna, D. / Halkowycz, P.
External linksBioorg. Med. Chem. Lett. / PubMed:28082036
MethodsX-ray diffraction
Resolution2.24 - 2.68 Å
Structure data

PDB-5tc0:
Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

PDB-5td2:
Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate
Method: X-RAY DIFFRACTION / Resolution: 2.68 Å

Chemicals

ChemComp-79Y:
N-(2-{4-[(2S)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}phenyl)-1H-imidazole-2-carboxamide

ChemComp-HOH:
WATER

ChemComp-7AE:
N-[2-{4-[(2S)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}-4-(morpholin-4-yl)phenyl]-1H-imidazole-2-carboxamide

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / kinase / inhibitor / surrogate / oncology / Transferase-Transferase Inhibitor complex

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