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TitleStructural and Functional Basis of C-Methylation of Coumarin Scaffolds by NovO.
Journal, issue, pagesACS Chem. Biol., Vol. 12, Page 374-379, Year 2017
Publish dateNov 22, 2016 (structure data deposition date)
AuthorsSadler, J.C. / Chung, C.H. / Mosley, J.E. / Burley, G.A. / Humphreys, L.D.
External linksACS Chem. Biol. / PubMed:28068060
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-5mgz:
Streptomyces Spheroides NovO (8-demethylnovbiocic acid methyltransferase) with SAH
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • streptomyces niveus (bacteria)
KeywordsTRANSFERASE / C methyltransferase / Novobiocin biosynthesis / SAM dependent

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