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TitleTwo Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.
Journal, issue, pagesACS Chem. Biol., Vol. 12, Page 548-557, Year 2017
Publish dateDec 19, 2016 (structure data deposition date)
AuthorsOrtega, M.A. / Cogan, D.P. / Mukherjee, S. / Garg, N. / Li, B. / Thibodeaux, G.N. / Maffioli, S.I. / Donadio, S. / Sosio, M. / Escano, J. ...Ortega, M.A. / Cogan, D.P. / Mukherjee, S. / Garg, N. / Li, B. / Thibodeaux, G.N. / Maffioli, S.I. / Donadio, S. / Sosio, M. / Escano, J. / Smith, L. / Nair, S.K. / van der Donk, W.A.
External linksACS Chem. Biol. / PubMed:28032983
MethodsX-ray diffraction
Resolution1.88 Å
Structure data

PDB-5uao:
Crystal structure of MibH, a lathipeptide tryptophan 5-halogenase
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • microbispora sp. atcc pta-5024 (bacteria)
KeywordsOXIDOREDUCTASE / halogenase / lanthipeptide / tryptophan / NAI-107

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