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TitleDiscovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
Journal, issue, pagesChemMedChem, Vol. 12, Page 207-213, Year 2017
Publish dateMay 17, 2016 (structure data deposition date)
AuthorsMcIver, A.L. / Zhang, W. / Liu, Q. / Jiang, X. / Stashko, M.A. / Nichols, J. / Miley, M.J. / Norris-Drouin, J. / Machius, M. / DeRyckere, D. ...McIver, A.L. / Zhang, W. / Liu, Q. / Jiang, X. / Stashko, M.A. / Nichols, J. / Miley, M.J. / Norris-Drouin, J. / Machius, M. / DeRyckere, D. / Wood, E. / Graham, D.K. / Earp, H.S. / Kireev, D. / Frye, S.V. / Wang, X.
External linksChemMedChem / PubMed:28032464
MethodsX-ray diffraction
Resolution2.231 Å
Structure data

PDB-5k0x:
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2541
Method: X-RAY DIFFRACTION / Resolution: 2.231 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-K0X:
(7S)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Macrocyclic / Drug Design / Fibrinolytic Agents / Protein Kinase Inhibitors / Proto-Oncogene Proteins / Pyrimidines / Receptor Protein-Tyrosine Kinases / Structure-Activity Relationship / Thrombosis / Transferase-Transferase Inhibitor complex

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