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-Structure paper
Title | Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 1746-1767, Year 2017 |
Publish date | Aug 17, 2016 (structure data deposition date) |
Authors | Coxon, C.R. / Anscombe, E. / Harnor, S.J. / Martin, M.P. / Carbain, B. / Golding, B.T. / Hardcastle, I.R. / Harlow, L.K. / Korolchuk, S. / Matheson, C.J. ...Coxon, C.R. / Anscombe, E. / Harnor, S.J. / Martin, M.P. / Carbain, B. / Golding, B.T. / Hardcastle, I.R. / Harlow, L.K. / Korolchuk, S. / Matheson, C.J. / Newell, D.R. / Noble, M.E. / Sivaprakasam, M. / Tudhope, S.J. / Turner, D.M. / Wang, L.Z. / Wedge, S.R. / Wong, C. / Griffin, R.J. / Endicott, J.A. / Cano, C. |
External links | J. Med. Chem. / PubMed:28005359 |
Methods | X-ray diffraction |
Resolution | 2.06 - 2.97 Å |
Structure data | PDB-5lqf: PDB-5nev: |
Chemicals | ChemComp-4SP: ChemComp-HOH: ChemComp-72L: |
Source |
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Keywords | TRANSFERASE / CDK1 CYCLIN B CKS2 CELL CYCLE NU6102 / CDK2 CYCLIN A / CDK2 SELECTIVE TRANSFERASE |