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Title | Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity. |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 10974-10993, Year 2016 |
Publish date | Jul 25, 2016 (structure data deposition date) |
Authors | Chappell, M.D. / Li, R. / Smith, S.C. / Dressman, B.A. / Tromiczak, E.G. / Tripp, A.E. / Blanco, M.J. / Vetman, T. / Quimby, S.J. / Matt, J. ...Chappell, M.D. / Li, R. / Smith, S.C. / Dressman, B.A. / Tromiczak, E.G. / Tripp, A.E. / Blanco, M.J. / Vetman, T. / Quimby, S.J. / Matt, J. / Britton, T.C. / Fivush, A.M. / Schkeryantz, J.M. / Mayhugh, D. / Erickson, J.A. / Bures, M.G. / Jaramillo, C. / Carpintero, M. / Diego, J.E. / Barberis, M. / Garcia-Cerrada, S. / Soriano, J.F. / Antonysamy, S. / Atwell, S. / MacEwan, I. / Condon, B. / Sougias, C. / Wang, J. / Zhang, A. / Conners, K. / Groshong, C. / Wasserman, S.R. / Koss, J.W. / Witkin, J.M. / Li, X. / Overshiner, C. / Wafford, K.A. / Seidel, W. / Wang, X.S. / Heinz, B.A. / Swanson, S. / Catlow, J.T. / Bedwell, D.W. / Monn, J.A. / Mitch, C.H. / Ornstein, P.L. |
External links | PubMed:28002967 |
Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | PDB-5kzn: PDB-5kzq: |
Chemicals | ChemComp-NAG: ChemComp-MG: ChemComp-HOH: ChemComp-6YS: |
Source |
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Keywords | SIGNALING PROTEIN / mGluR2 / antagonist / antidepressent |