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TitleA crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Journal, issue, pagesNat Commun, Vol. 7, Page 13609-13609, Year 2016
Publish dateMar 7, 2016 (structure data deposition date)
AuthorsRay, L. / Valentic, T.R. / Miyazawa, T. / Withall, D.M. / Song, L. / Milligan, J.C. / Osada, H. / Takahashi, S. / Tsai, S.C. / Challis, G.L.
External linksNat Commun / PubMed:28000660
MethodsX-ray diffraction
Resolution2.45 - 2.85 Å
Structure data

PDB-5inf:
Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics
Method: X-RAY DIFFRACTION / Resolution: 2.751 Å

PDB-5ing:
A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender unit
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-5ini:
Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-HXC:
HEXANOYL-COENZYME A

ChemComp-HOH:
WATER

Source
  • streptomyces ambofaciens atcc 23877 (bacteria)
KeywordsTRANSFERASE / Polyketide / Crotonase / Extender-Unit / Acyl-CoA

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