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TitleNeurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
Journal, issue, pagesElife, Vol. 5, Year 2016
Publish dateNov 4, 2015 (structure data deposition date)
AuthorsKober, D.L. / Alexander-Brett, J.M. / Karch, C.M. / Cruchaga, C. / Colonna, M. / Holtzman, M.J. / Brett, T.J.
External linksElife / PubMed:27995897
MethodsX-ray diffraction
Resolution3.0977 Å
Structure data

PDB-5eli:
Triggering receptor expressed on myeloid cells 2
Method: X-RAY DIFFRACTION / Resolution: 3.0977 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Activating receptors / TREM2 / innate immunity / immune system receptor

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