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TitleCyclic AMP Inhibits the Activity and Promotes the Acetylation of Acetyl-CoA Synthetase through Competitive Binding to the ATP/AMP Pocket.
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 1374-1384, Year 2017
Publish dateMay 6, 2016 (structure data deposition date)
AuthorsHan, X. / Shen, L. / Wang, Q. / Cen, X. / Wang, J. / Wu, M. / Li, P. / Zhao, W. / Zhang, Y. / Zhao, G.
External linksJ. Biol. Chem. / PubMed:27974467
MethodsX-ray diffraction
Resolution1.644 Å
Structure data

PDB-5jrh:
Crystal structure of Salmonella enterica acetyl-CoA synthetase (Acs) in complex with cAMP and Coenzyme A
Method: X-RAY DIFFRACTION / Resolution: 1.644 Å

Chemicals

ChemComp-COA:
COENZYME A

ChemComp-CMP:
ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

ChemComp-HOH:
WATER

Source
  • salmonella typhimurium (strain lt2 / sgsc1412 / atcc 700720) (bacteria)
KeywordsLIGASE / acetyl-Coenzyme A synthetase / cAMP / AMP-forming / acetyl-Coenzyme A

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