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TitleStructural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R alpha 1 and IL-13R alpha 2.
Journal, issue, pagesJ. Mol. Biol., Vol. 429, Page 208-219, Year 2017
Publish dateJun 1, 2016 (structure data deposition date)
AuthorsPopovic, B. / Breed, J. / Rees, D.G. / Gardener, M.J. / Vinall, L.M. / Kemp, B. / Spooner, J. / Keen, J. / Minter, R. / Uddin, F. ...Popovic, B. / Breed, J. / Rees, D.G. / Gardener, M.J. / Vinall, L.M. / Kemp, B. / Spooner, J. / Keen, J. / Minter, R. / Uddin, F. / Colice, G. / Wilkinson, T. / Vaughan, T. / May, R.D.
External linksJ. Mol. Biol. / PubMed:27956146
MethodsX-ray diffraction
Resolution1.99 Å
Structure data

PDB-5l6y:
il13 in complex with tralokinumab
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

Chemicals

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IL13 antibody tralokinumab asthma / IL13

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