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TitleStructural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed.
Journal, issue, pagesPLoS ONE, Vol. 11, Page e0168019-e0168019, Year 2016
Publish dateOct 21, 2016 (structure data deposition date)
AuthorsChoi, Y.M. / Yeo, H.K. / Park, Y.W. / Lee, J.Y.
External linksPLoS ONE / PubMed:27936107
MethodsX-ray diffraction
Resolution1.7 - 2.4 Å
Structure data

PDB-5h38:
Structural analysis of KSHV thymidylate synthase
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5h39:
Structural analysis of KSHV thymidylate synthase
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5h3a:
Structural analysis of KSHV thymidylate synthase
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-UMP:
2'-DEOXYURIDINE 5'-MONOPHOSPHATE

ChemComp-D16:
TOMUDEX / chemotherapy, inhibitor*YM

Source
  • human herpesvirus 8
KeywordsTRANSFERASE / thymidylate synthase / inhibitor / raltitrexed / dUMP

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