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TitleInhibition of RAS function through targeting an allosteric regulatory site.
Journal, issue, pagesNat. Chem. Biol., Vol. 13, Page 62-68, Year 2017
Publish dateOct 14, 2015 (structure data deposition date)
AuthorsSpencer-Smith, R. / Koide, A. / Zhou, Y. / Eguchi, R.R. / Sha, F. / Gajwani, P. / Santana, D. / Gupta, A. / Jacobs, M. / Herrero-Garcia, E. ...Spencer-Smith, R. / Koide, A. / Zhou, Y. / Eguchi, R.R. / Sha, F. / Gajwani, P. / Santana, D. / Gupta, A. / Jacobs, M. / Herrero-Garcia, E. / Cobbert, J. / Lavoie, H. / Smith, M. / Rajakulendran, T. / Dowdell, E. / Okur, M.N. / Dementieva, I. / Sicheri, F. / Therrien, M. / Hancock, J.F. / Ikura, M. / Koide, S. / O'Bryan, J.P.
External linksNat. Chem. Biol. / PubMed:27820802
MethodsX-ray diffraction
Resolution1.402 Å
Structure data

PDB-5e95:
Crystal Structure of Mb(NS1)/H-Ras Complex
Method: X-RAY DIFFRACTION / Resolution: 1.402 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/INHIBITOR / H-Ras / Monobody / Inhibitor / Complex / SIGNALING PROTEIN-INHIBITOR complex

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