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TitleHow Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation.
Journal, issue, pagesStructure, Vol. 24, Page 2182-2189, Year 2016
Publish dateSep 18, 2015 (structure data deposition date)
AuthorsDijk, M. / Holkers, J. / Voskamp, P. / Giannetti, B.M. / Waterreus, W.J. / van Veen, H.A. / Pannu, N.S.
External linksStructure / PubMed:27818099
MethodsX-ray diffraction
Resolution2.1 - 2.9 Å
Structure data

PDB-5du3:
Active form of human C1-inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-5duq:
Active human c1-inhibitor in complex with dextran sulfate
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GLC:
alpha-D-glucopyranose

ChemComp-SO3:
SULFITE ION

Source
  • homo sapiens (human)
Keywordshydrolase inhibitor / Serine protease inhibitor / HYDROLASE / Serine protein inhibitor / Complex with Glycosaminoglycan

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