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-Structure paper
Title | Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 26, Page 5729-5731, Year 2016 |
Publish date | Oct 18, 2016 (structure data deposition date) |
Authors | Wu, Y.J. / Guernon, J. / Rajamani, R. / Toyn, J.H. / Ahlijanian, M.K. / Albright, C.F. / Muckelbauer, J. / Chang, C. / Camac, D. / Macor, J.E. / Thompson, L.A. |
External links | Bioorg. Med. Chem. Lett. / PubMed:27816517 |
Methods | X-ray diffraction |
Resolution | 2.51 Å |
Structure data | PDB-5tol: |
Chemicals | ChemComp-7H3: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / ASPARTYL PROTEASE / BACE1 / KIAA1149 / ASP2 / FLJ90568 / BACE / HSPC104 |