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Structure paper

TitleCrystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding.
Journal, issue, pagesProteins, Vol. 85, Page 117-124, Year 2017
Publish dateJan 22, 2016 (structure data deposition date)
AuthorsCrochet, R.B. / Kim, J.D. / Lee, H. / Yim, Y.S. / Kim, S.G. / Neau, D. / Lee, Y.H.
External linksProteins / PubMed:27802586
MethodsX-ray diffraction
Resolution1.82 - 2.01 Å
Structure data

PDB-5hr5:
Bovine Heart 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFKFB2)
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-5htk:
Human Heart 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFKFB2)
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

Chemicals

ChemComp-DIO:
1,4-DIETHYLENE DIOXIDE

ChemComp-F6P:
6-O-phosphono-beta-D-fructofuranose

ChemComp-FLC:
CITRATE ANION

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • bos taurus (domestic cattle)
  • homo sapiens (human)
KeywordsHydrolase / Transferase / Bovine PFKFB2 / Human PFKFB2

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