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-Structure paper
Title | Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. |
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Journal, issue, pages | ACS Chem. Biol., Vol. 11, Page 3442-3451, Year 2016 |
Publish date | Oct 19, 2016 (structure data deposition date) |
Authors | Telliez, J.B. / Dowty, M.E. / Wang, L. / Jussif, J. / Lin, T. / Li, L. / Moy, E. / Balbo, P. / Li, W. / Zhao, Y. ...Telliez, J.B. / Dowty, M.E. / Wang, L. / Jussif, J. / Lin, T. / Li, L. / Moy, E. / Balbo, P. / Li, W. / Zhao, Y. / Crouse, K. / Dickinson, C. / Symanowicz, P. / Hegen, M. / Banker, M.E. / Vincent, F. / Unwalla, R. / Liang, S. / Gilbert, A.M. / Brown, M.F. / Hayward, M. / Montgomery, J. / Yang, X. / Bauman, J. / Trujillo, J.I. / Casimiro-Garcia, A. / Vajdos, F.F. / Leung, L. / Geoghegan, K.F. / Quazi, A. / Xuan, D. / Jones, L. / Hett, E. / Wright, K. / Clark, J.D. / Thorarensen, A. |
External links | ACS Chem. Biol. / PubMed:27791347 |
Methods | X-ray diffraction |
Resolution | 1.98 Å |
Structure data | PDB-5toz: |
Chemicals | ChemComp-7H4: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE inhibitor / JAK3 covalent kinase / TRANSFERASE-TRANSFERASE inhibitor complex |