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Structure paper

TitleStructural basis of recognition of farnesylated and methylated KRAS4b by PDE delta.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 113, Page E6766-E6775, Year 2016
Publish dateSep 10, 2016 (structure data deposition date)
AuthorsDharmaiah, S. / Bindu, L. / Tran, T.H. / Gillette, W.K. / Frank, P.H. / Ghirlando, R. / Nissley, D.V. / Esposito, D. / McCormick, F. / Stephen, A.G. / Simanshu, D.K.
External linksProc. Natl. Acad. Sci. USA / PubMed:27791178
MethodsX-ray diffraction
Resolution1.9 - 2 Å
Structure data

PDB-5tar:
Crystal structure of farnesylated and methylated kras4b in complex with PDE-delta (crystal form II - with ordered hypervariable region)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-5tb5:
Crystal structure of full-length farnesylated and methylated KRAS4b in complex with PDE-delta (crystal form I - with partially disordered hypervariable region)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-FAR:
FARNESYL

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / KRAS / KRAS4b / PDE6delta / PDEdelta / RAS

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