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Structure paper

TitleStructural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.
Journal, issue, pagesACS Infect Dis., Vol. 3, Page 132-143, Year 2017
Publish dateMar 20, 2012 (structure data deposition date)
AuthorsStogios, P.J. / Kuhn, M.L. / Evdokimova, E. / Law, M. / Courvalin, P. / Savchenko, A.
External linksACS Infect Dis. / PubMed:27785912
MethodsX-ray diffraction
Resolution1.768 - 2.56 Å
Structure data

PDB-4e8o:
Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ih from Acinetobacter baumannii
Method: X-RAY DIFFRACTION / Resolution: 2.138 Å

PDB-4evy:
Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ig from Acinetobacter haemolyticus in complex with tobramycin
Method: X-RAY DIFFRACTION / Resolution: 1.768 Å

PDB-4f0y:
Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-IG from Acinetobacter haemolyticus, apo
Method: X-RAY DIFFRACTION / Resolution: 2.56 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-TOY:
TOBRAMYCIN / antibiotic*YM

ChemComp-K:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

Source
  • acinetobacter baumannii (bacteria)
  • acinetobacter haemolyticus (bacteria)
KeywordsTRANSFERASE / antibiotic resistance / Center for Structural Genomics of Infectious Diseases (CSGID) / NIAID / National Institute of Allergy and Infectious Diseases / GNAT superfamily / GCN5-related N-acetyltransferase superfamily / N-acetyltransferase fold / aminoglycoside antibiotic 6'-N-acetyltransferase / aminoglycoside antibiotics / acetyl coenzyme A / coenzyme A / intracellular / TRANSFERASE/ANTIBIOTIC / TRANSFERASE-ANTIBIOTIC complex / aminoglycosides

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