タイトル | A unique peptide deformylase platform to rationally design and challenge novel active compounds. |
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ジャーナル・号・ページ | Sci Rep, Vol. 6, Page 35429-35429, Year 2016 |
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掲載日 | 2016年4月19日 (構造データの登録日) |
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著者 | Fieulaine, S. / Alves de Sousa, R. / Maigre, L. / Hamiche, K. / Alimi, M. / Bolla, J.M. / Taleb, A. / Denis, A. / Pages, J.M. / Artaud, I. ...Fieulaine, S. / Alves de Sousa, R. / Maigre, L. / Hamiche, K. / Alimi, M. / Bolla, J.M. / Taleb, A. / Denis, A. / Pages, J.M. / Artaud, I. / Meinnel, T. / Giglione, C. |
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リンク | Sci Rep / PubMed:27762275 |
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手法 | X線回折 |
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解像度 | 1.6 - 2.8 Å |
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構造データ | PDB-5jex: Crystal structure of type 2 PDF from Streptococcus agalactiae, crystallized in imidazole buffer 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5jey: Crystal structure of type 2 PDF from Streptococcus agalactiae, crystallized in cacodylate buffer 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-5jez: Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with tripeptide Met-Ala-Ser 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5jf0: Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with tripeptide Met-Ala-Arg 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-5jf1: Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with actinonin 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5jf2: Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor AT002 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-5jf3: Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor AT018 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-5jf4: Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor AT019 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-5jf5: Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor AT020 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-5jf6: Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor 6b (AB47) 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-5jf7: Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor SMP289 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-5jf8: Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor RAS358 (21) 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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化合物 | ChemComp-SF7: (3R)-3-{3-[(4-fluorophenyl)methyl]-1,2,4-oxadiazol-5-yl}-N-hydroxyheptanamide
ChemComp-SF5: methyl 4-({5-[(3R)-1-(hydroxyamino)-1-oxoheptan-3-yl]-1,2,4-oxadiazol-3-yl}methyl)benzoate
ChemComp-6JT: (3R)-3-{3-[(1-benzofuran-3-yl)methyl]-1,2,4-oxadiazol-5-yl}-4-cyclopentyl-N-hydroxybutanamide
ChemComp-7JT: (3R)-3-{3-[(2H-1,3-benzodioxol-5-yl)methyl]-1,2,4-oxadiazol-5-yl}-4-cyclopentyl-N-hydroxybutanamide
ChemComp-6JU: 2-(3-benzyl-5-bromo-1H-indol-1-yl)-N-hydroxyacetamide
ChemComp-PN3: tert-butyl {(2S)-1-[formyl(hydroxy)amino]-3-phenylpropan-2-yl}carbamate
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由来 | streptococcus agalactiae (バクテリア)![](img/tx_bacteria.gif) escherichia coli (大腸菌)
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キーワード | HYDROLASE / PDF / type 2 / NME / N-terminal methionine excision / Streptococcus agalactiae / inhibitor / tripeptide / actinonin / AT002 / AT018 / AT019 / AT020 / 6b / AB47 / SMP289 / RAS358 |
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