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TitlePromiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Journal, issue, pagesSci Adv, Vol. 2, Page e1600760-e1600760, Year 2016
Publish dateFeb 28, 2016 (structure data deposition date)
AuthorsPicaud, S. / Leonards, K. / Lambert, J.P. / Dovey, O. / Wells, C. / Fedorov, O. / Monteiro, O. / Fujisawa, T. / Wang, C.Y. / Lingard, H. ...Picaud, S. / Leonards, K. / Lambert, J.P. / Dovey, O. / Wells, C. / Fedorov, O. / Monteiro, O. / Fujisawa, T. / Wang, C.Y. / Lingard, H. / Tallant, C. / Nikbin, N. / Guetzoyan, L. / Ingham, R. / Ley, S.V. / Brennan, P. / Muller, S. / Samsonova, A. / Gingras, A.C. / Schwaller, J. / Vassiliou, G. / Knapp, S. / Filippakopoulos, P.
External linksSci Adv / PubMed:27757418
MethodsX-ray diffraction
Resolution1.6 - 2.1 Å
Structure data

PDB-5igk:
Crystal structure of the first bromodomain of human BRD4 in complex with bromosporine (BSP)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5igl:
Crystal structure of the second bromodomain of human TAF1L in complex with bromosporine (BSP)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-5igm:
Crystal structure of the bromodomain of human BRD9 in complex with bromosporine (BSP)
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-BMF:
Bromosporine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / post translational modifications / BET family / Structural Genomics / Structural Genomics Consortium / SGC / TAF1/TAFII250 / chromatin remodeling

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