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TitleRational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing.
Journal, issue, pagesJ. Med. Chem., Vol. 59, Page 10190-10197, Year 2016
Publish dateSep 5, 2016 (structure data deposition date)
AuthorsJagtap, P.K. / Garg, D. / Kapp, T.G. / Will, C.L. / Demmer, O. / Luhrmann, R. / Kessler, H. / Sattler, M.
External linksJ. Med. Chem. / PubMed:27753493
MethodsX-ray diffraction
Resolution2.22 Å
Structure data

PDB-5lso:
Crystal structure of SPF45 UHM domain with cyclic peptide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.22 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSplicing/Inhibitor / UHM domain / Splicing-inhibitor complex

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