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Structure paper

TitleMolecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Journal, issue, pagesMol. Cell, Vol. 64, Page 307-319, Year 2016
Publish dateFeb 1, 2016 (structure data deposition date)
AuthorsCretu, C. / Schmitzova, J. / Ponce-Salvatierra, A. / Dybkov, O. / De Laurentiis, E.I. / Sharma, K. / Will, C.L. / Urlaub, H. / Luhrmann, R. / Pena, V.
External linksMol. Cell / PubMed:27720643
MethodsX-ray diffraction
Resolution2.9 - 3.1 Å
Structure data

PDB-5hy7:
SF3B10-SF3B130 from Chaetomium thermophilum
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-5ife:
Crystal structure of the human SF3b core complex
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-K:
Unknown entry

Source
  • chaetomium thermophilum var. thermophilum dsm 1495 (fungus)
  • homo sapiens (human)
KeywordsPROTEIN BINDING / spliceosome / complex / WD40s / Hydrolase / SPLICING / pre-mRNA splicing / U2 snRNP / essential splicing factor

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