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TitleA Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
Journal, issue, pagesACS Chem. Biol., Vol. 11, Page 3310-3318, Year 2016
Publish dateApr 21, 2015 (structure data deposition date)
AuthorsSurmiak, E. / Twarda-Clapa, A. / Zak, K.M. / Musielak, B. / Tomala, M.D. / Kubica, K. / Grudnik, P. / Madej, M. / Jablonski, M. / Potempa, J. ...Surmiak, E. / Twarda-Clapa, A. / Zak, K.M. / Musielak, B. / Tomala, M.D. / Kubica, K. / Grudnik, P. / Madej, M. / Jablonski, M. / Potempa, J. / Kalinowska-Tluscik, J. / Domling, A. / Dubin, G. / Holak, T.A.
External linksACS Chem. Biol. / PubMed:27709883
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4zfi:
Structure of Mdm2 with low molecular weight inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4zgk:
Structure of Mdm2 with low molecular weight inhibitor.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-4NJ:
(5S)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxy-1-methyl-1,5-dihydro-2H-pyrrol-2-one

ChemComp-HOH:
WATER

ChemComp-4NX:
(5R)-3,5-bis(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-hydroxyfuran-2(5H)-one

Source
  • homo sapiens (human)
KeywordsLIGASE / p53-binding protein Mdm2 / Oncoprotein Mdm2 / Double minute 2 protein / Hdm2 / small molecule inhibitor / p53-Mdm2/MdmX interaction / inhibitor

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