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Structure paper

TitleStructural basis for PPAR partial or full activation revealed by a novel ligand binding mode.
Journal, issue, pagesSci Rep, Vol. 6, Page 34792-34792, Year 2016
Publish dateFeb 1, 2016 (structure data deposition date)
AuthorsCapelli, D. / Cerchia, C. / Montanari, R. / Loiodice, F. / Tortorella, P. / Laghezza, A. / Cervoni, L. / Pochetti, G. / Lavecchia, A.
External linksSci Rep / PubMed:27708429
MethodsX-ray diffraction
Resolution1.83 - 2 Å
Structure data

PDB-5hyk:
Crystal structure of the complex PPARalpha/AL26-29
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

PDB-5hzc:
Crystal structure of the complex PPARgamma/AL26-29
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-65W:
2-methyl-2-[4-(naphthalen-1-yl)phenoxy]propanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Nuclear receptor / transcription factor / diabetes / bundle of alpha-helices

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