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-Structure paper
Title | Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 24, Page 5534-5545, Year 2016 |
Publish date | Aug 29, 2016 (structure data deposition date) |
Authors | Pissarnitski, D.A. / Zhao, Z. / Cole, D. / Wu, W.L. / Domalski, M. / Clader, J.W. / Scapin, G. / Voigt, J. / Soriano, A. / Kelly, T. ...Pissarnitski, D.A. / Zhao, Z. / Cole, D. / Wu, W.L. / Domalski, M. / Clader, J.W. / Scapin, G. / Voigt, J. / Soriano, A. / Kelly, T. / Powles, M.A. / Yao, Z. / Burnett, D.A. |
External links | Bioorg. Med. Chem. / PubMed:27670099 |
Methods | X-ray diffraction |
Resolution | 1.76 - 2.61 Å |
Structure data | PDB-5t4b: PDB-5t4e: PDB-5t4f: PDB-5t4h: |
Chemicals | ChemComp-NAG: ChemComp-75N: ChemComp-NA: ChemComp-HOH: ChemComp-75L: ChemComp-75M: ChemComp-75J: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / Structure-based drug design / diabetes / DPP4 inhibitors / hydrolase / Hydrolase-Hydrolase Inhibitor complex |