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TitleThe Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance.
Journal, issue, pagesPlos One, Vol. 11, Page e0163366-e0163366, Year 2016
Publish dateAug 9, 2016 (structure data deposition date)
AuthorsSickmier, E.A. / Kurzeja, R.J. / Michelsen, K. / Vazir, M. / Yang, E. / Tasker, A.S.
External linksPlos One / PubMed:27658254
MethodsX-ray diffraction
Resolution2.5 - 2.8 Å
Structure data

PDB-5sx4:
Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3.
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-5sx5:
Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R.
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/IMMUNE SYSTEM / Cetuximab / panitumumab / EGFR / Vectibix / Erbitux / TRANSFERASE-IMMUNE SYSTEM complex

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