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TitleA histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.
Journal, issue, pagesElife, Vol. 5, Year 2016
Publish dateAug 16, 2016 (structure data deposition date)
AuthorsShan, C.M. / Wang, J. / Xu, K. / Chen, H. / Yue, J.X. / Andrews, S. / Moresco, J.J. / Yates, J.R. / Nagy, P.L. / Tong, L. / Jia, S.
External linksElife / PubMed:27648579
MethodsX-ray diffraction
Resolution1.7 - 1.896 Å
Structure data

PDB-5t0k:
Structure of G9a SET-domain with H3K9M mutant peptide and SAM
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5t0m:
A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading
Method: X-RAY DIFFRACTION / Resolution: 1.896 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SAM:
S-ADENOSYLMETHIONINE

ChemComp-HOH:
WATER

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / histone methyltransferase / SET domain

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