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TitleAffinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice.
Journal, issue, pagesHepatology, Vol. 64, Page 1922-1933, Year 2016
Publish dateMar 26, 2015 (structure data deposition date)
AuthorsKeck, Z.Y. / Wang, Y. / Lau, P. / Lund, G. / Rangarajan, S. / Fauvelle, C. / Liao, G.C. / Holtsberg, F.W. / Warfield, K.L. / Aman, M.J. ...Keck, Z.Y. / Wang, Y. / Lau, P. / Lund, G. / Rangarajan, S. / Fauvelle, C. / Liao, G.C. / Holtsberg, F.W. / Warfield, K.L. / Aman, M.J. / Pierce, B.G. / Fuerst, T.R. / Bailey, J.R. / Baumert, T.F. / Mariuzza, R.A. / Kneteman, N.M. / Foung, S.K.
External linksHepatology / PubMed:27641232
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-4z0x:
Structure of Hepatitis C Virus Envelope glycoprotein E2 antigenic region 434-446 bound to the broadly neutralizing antibody HC26AM
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • hepacivirus c
KeywordsIMMUNE SYSTEM / HCV / Broadly neutralizing Antibody

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