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TitleOn-target efficacy of a HIF-2 alpha antagonist in preclinical kidney cancer models.
Journal, issue, pagesNature, Vol. 539, Page 107-111, Year 2016
Publish dateJan 5, 2017 (structure data deposition date)
AuthorsCho, H. / Du, X. / Rizzi, J.P. / Liberzon, E. / Chakraborty, A.A. / Gao, W. / Carvo, I. / Signoretti, S. / Bruick, R.K. / Josey, J.A. ...Cho, H. / Du, X. / Rizzi, J.P. / Liberzon, E. / Chakraborty, A.A. / Gao, W. / Carvo, I. / Signoretti, S. / Bruick, R.K. / Josey, J.A. / Wallace, E.M. / Kaelin, W.G.
External linksNature / PubMed:27595393
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-5ufp:
Crystal structure of PT2399 bound to HIF2a-B*:ARNT-B* complex
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-86D:
3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / HIF2 inhibitor HIF2 ligand PAS-B hypoxia inducible factor 2 EPAS1

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