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TitleSmall molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.
Journal, issue, pagesNature, Vol. 537, Page 112-116, Year 2016
Publish dateJun 22, 2016 (structure data deposition date)
AuthorsDhawan, N.S. / Scopton, A.P. / Dar, A.C.
External linksNature / PubMed:27556948
MethodsX-ray diffraction
Resolution3.509 Å
Structure data

PDB-5kkr:
KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79
Method: X-RAY DIFFRACTION / Resolution: 3.509 Å

Chemicals

ChemComp-6U7:
6,7-dimethoxy-~{N}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine

Source
  • homo sapiens (human)
  • oryctolagus cuniculus (rabbit)
KeywordsTRANSFERASE / Kinase Suppressor of Ras Small Molecule Complex

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