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TitleMechanism of Error-Free Bypass of the Environmental Carcinogen N-(2'-Deoxyguanosin-8-yl)-3-aminobenzanthrone Adduct by Human DNA Polymerase eta.
Journal, issue, pagesChembiochem, Vol. 17, Page 2033-2037, Year 2016
Publish dateMay 10, 2016 (structure data deposition date)
AuthorsPatra, A. / Politica, D.A. / Chatterjee, A. / Tokarsky, E.J. / Suo, Z. / Basu, A.K. / Stone, M.P. / Egli, M.
External linksChembiochem / PubMed:27556902
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-5jum:
Crystal Structure of Human DNA Polymerase Eta Inserting dCTP Opposite N-(2'-deoxyguanosin-8- yl)-3-aminobenzanthrone (C8-dG-ABA)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
Keywordstransferase/dna / Environmental Carcinogen / Catalytic Domain / Protein / DNA / DNA Damage / DNA-Directed DNA Polymerase / Guanosine Triphosphate / Y-family polymerase / trans-lesion synthesis (TLS) / Polymerase Eta / DNA Binding / 3-Nitrobenzanthrone / N-(2'-deoxyguanosin-8- yl)-3-aminobenzanthrone (C8-dG-ABA). / transferase-dna complex

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