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| Title | Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors. |
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| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 26, Page 4824-4828, Year 2016 |
| Publish date | May 17, 2016 (structure data deposition date) |
 Authors | Kuklish, S.L. / Antonysamy, S. / Bhattachar, S.N. / Chandrasekhar, S. / Fisher, M.J. / Fretland, A.J. / Gooding, K. / Harvey, A. / Hughes, N.E. / Luz, J.G. ...Kuklish, S.L. / Antonysamy, S. / Bhattachar, S.N. / Chandrasekhar, S. / Fisher, M.J. / Fretland, A.J. / Gooding, K. / Harvey, A. / Hughes, N.E. / Luz, J.G. / Manninen, P.R. / McGee, J.E. / Navarro, A. / Norman, B.H. / Partridge, K.M. / Quimby, S.J. / Schiffler, M.A. / Sloan, A.V. / Warshawsky, A.M. / York, J.S. / Yu, X.P. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:27554445 |
| Methods | X-ray diffraction |
| Resolution | 1.3 Å |
| Structure data |  PDB-5k0i: |
| Chemicals |  ChemComp-6PW:  ChemComp-GSH:  ChemComp-BOG:  ChemComp-PG4:  ChemComp-HOH: |
| Source |
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 Keywords | Isomerase/Isomerase Inhibitor / mpges1 / inhibitor / pain / inflammation / Isomerase-Isomerase Inhibitor complex |
homo sapiens (human)