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Title | Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153). |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 7801-7817, Year 2016 |
Publish date | Jun 15, 2016 (structure data deposition date) |
Authors | Bradbury, R.H. / Callis, R. / Carr, G.R. / Chen, H. / Clark, E. / Feron, L. / Glossop, S. / Graham, M.A. / Hattersley, M. / Jones, C. ...Bradbury, R.H. / Callis, R. / Carr, G.R. / Chen, H. / Clark, E. / Feron, L. / Glossop, S. / Graham, M.A. / Hattersley, M. / Jones, C. / Lamont, S.G. / Ouvry, G. / Patel, A. / Patel, J. / Rabow, A.A. / Roberts, C.A. / Stokes, S. / Stratton, N. / Walker, G.E. / Ward, L. / Whalley, D. / Whittaker, D. / Wrigley, G. / Waring, M.J. |
External links | J. Med. Chem. / PubMed:27528113 |
Methods | X-ray diffraction |
Resolution | 1.48 Å |
Structure data | PDB-5khm: |
Chemicals | ChemComp-XNH: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | Transcription Factor / bromodomain |