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-Structure paper
Title | Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 59, Page 7544-7560, Year 2016 |
Publish date | Mar 17, 2016 (structure data deposition date) |
Authors | Glatthar, R. / Stojanovic, A. / Troxler, T. / Mattes, H. / Mobitz, H. / Beerli, R. / Blanz, J. / Gassmann, E. / Druckes, P. / Fendrich, G. ...Glatthar, R. / Stojanovic, A. / Troxler, T. / Mattes, H. / Mobitz, H. / Beerli, R. / Blanz, J. / Gassmann, E. / Druckes, P. / Fendrich, G. / Gutmann, S. / Martiny-Baron, G. / Spence, F. / Hornfeld, J. / Peel, J.E. / Sparrer, H. |
External links | J. Med. Chem. / PubMed:27502541 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-5iu2: |
Chemicals | ChemComp-6DA: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / COT / Tpl-2 / MAP3K8 / kinase / inhibitor / complex |