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-Structure paper
Title | Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR. |
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Journal, issue, pages | Angew. Chem. Int. Ed. Engl., Vol. 55, Page 10909-10912, Year 2016 |
Publish date | Apr 11, 2016 (structure data deposition date) |
Authors | Engel, J. / Becker, C. / Lategahn, J. / Keul, M. / Ketzer, J. / Muhlenberg, T. / Kollipara, L. / Schultz-Fademrecht, C. / Zahedi, R.P. / Bauer, S. / Rauh, D. |
External links | Angew. Chem. Int. Ed. Engl. / PubMed:27496389 |
Methods | X-ray diffraction |
Resolution | 2.5 - 2.8 Å |
Structure data | PDB-5j9y: PDB-5j9z: |
Chemicals | ChemComp-6HL: ChemComp-HOH: ChemComp-6HJ: |
Source |
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Keywords | TRANSFERASE / tyrosine kinase / covalent inhibitor / drug resistance |