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TitleBacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor.
Journal, issue, pagesAppl. Microbiol. Biotechnol., Vol. 100, Page 10521-10529, Year 2016
Publish dateFeb 16, 2016 (structure data deposition date)
AuthorsKim, J.H. / Sim, D.W. / Park, D. / Jung, T.G. / Lee, S. / Oh, T. / Ha, J.R. / Seok, S.H. / Seo, M.D. / Kang, H.C. ...Kim, J.H. / Sim, D.W. / Park, D. / Jung, T.G. / Lee, S. / Oh, T. / Ha, J.R. / Seok, S.H. / Seo, M.D. / Kang, H.C. / Kim, Y.P. / Won, H.S.
External linksAppl. Microbiol. Biotechnol. / PubMed:27470143
MethodsX-ray diffraction
Resolution1.922 Å
Structure data

PDB-5i76:
Crystal structure of FM318, a recombinant Fab adopted from cetuximab
Method: X-RAY DIFFRACTION / Resolution: 1.922 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens/mus musculus xenograft (mammal)
KeywordsIMMUNE SYSTEM / Antibody fragment / Recombinant Fab / Cetuximab / EGFR

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