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TitleDeveloping Anticancer Ferric Prodrugs Based on the N-Donor Residues of Human Serum Albumin Carrier IIA Subdomain
Journal, issue, pagesJ. Med. Chem., Vol. 59, Page 7497-7511, Year 2016
Publish dateJun 25, 2016 (structure data deposition date)
AuthorsQi, J. / Gou, Y. / Zhang, Y. / Yang, K. / Chen, S. / Liu, L. / Wu, X. / Wang, T. / Zhang, W. / Yang, F.
External linksJ. Med. Chem. / PubMed:27441502
MethodsX-ray diffraction
Resolution2.801 Å
Structure data

PDB-5gix:
Human serum albumin-Palmitic acid-Fe(Hn3piT)Cl2
Method: X-RAY DIFFRACTION / Resolution: 2.801 Å

Chemicals

ChemComp-6WF:
14-piperidin-1-yl-11-oxa-13$l^{3}-thia-15,16$l^{4}-diaza-12$l^{3}-ferratetracyclo[8.7.0.0^{2,7}.0^{12,16}]heptadeca-1(10),2(7),3,5,8,13,16-heptaene

ChemComp-PLM:
PALMITIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / ferric compound / anticancer mechanism / tumor targeting / therapeutic effect

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