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Structure paper

TitleStructural mechanism of ligand activation in human calcium-sensing receptor.
Journal, issue, pagesElife, Vol. 5, Year 2016
Publish dateMay 23, 2016 (structure data deposition date)
AuthorsGeng, Y. / Mosyak, L. / Kurinov, I. / Zuo, H. / Sturchler, E. / Cheng, T.C. / Subramanyam, P. / Brown, A.P. / Brennan, S.C. / Mun, H.C. ...Geng, Y. / Mosyak, L. / Kurinov, I. / Zuo, H. / Sturchler, E. / Cheng, T.C. / Subramanyam, P. / Brown, A.P. / Brennan, S.C. / Mun, H.C. / Bush, M. / Chen, Y. / Nguyen, T.X. / Cao, B. / Chang, D.D. / Quick, M. / Conigrave, A.D. / Colecraft, H.M. / McDonald, P. / Fan, Q.R.
External linksElife / PubMed:27434672
MethodsX-ray diffraction
Resolution2.6 - 3.1 Å
Structure data

PDB-5k5s:
Crystal structure of the active form of human calcium-sensing receptor extracellular domain
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5k5t:
Crystal structure of the inactive form of human calcium-sensing receptor extracellular domain
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-TRP:
TRYPTOPHAN

ChemComp-PO4:
PHOSPHATE ION

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Venus Flytrap module / cysteine-rich domain / homodimer / cysteine rich domain

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