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Structure paper

TitleStructures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate.
Journal, issue, pagesPlos One, Vol. 11, Page e0159154-e0159154, Year 2016
Publish dateApr 28, 2015 (structure data deposition date)
AuthorsAbabou, A. / Koronakis, V.
External linksPlos One / PubMed:27403665
MethodsX-ray diffraction
Resolution3.16 - 3.6 Å
Structure data

PDB-4zit:
Crystal structure of AcrB in P21 space group
Method: X-RAY DIFFRACTION / Resolution: 3.296 Å

PDB-4ziv:
Crystal structure of AcrB triple mutant in P21 space group
Method: X-RAY DIFFRACTION / Resolution: 3.16 Å

PDB-4ziw:
Crystal structure of AcrB deletion mutant in P21 space group
Method: X-RAY DIFFRACTION / Resolution: 3.399 Å

PDB-4zjl:
Crystal structure of AcrB in complex with antibiotic in P21 space group
Method: X-RAY DIFFRACTION / Resolution: 3.47 Å

PDB-4zjo:
Crystal structure of AcrB triple mutant in complex with antibiotic in P21 space group
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

PDB-4zjq:
Crystal structure of AcrB deletion mutant in complex with antibiotic in P21 space group
Method: X-RAY DIFFRACTION / Resolution: 3.592 Å

Chemicals

ChemComp-LMT:
DODECYL-BETA-D-MALTOSIDE / detergent*YM

ChemComp-NI:
NICKEL (II) ION

ChemComp-ERY:
ERYTHROMYCIN A / antibiotic*YM

Source
  • escherichia coli k-12 (bacteria)
  • escherichia coli (strain k12) (bacteria)
  • escherichia coli str. k-12 substr. mg1655 (bacteria)
KeywordsTRANSPORT PROTEIN / AcrB / RND Efflux pump / Bacterial multidrug resistance / Export mechanism / AcrB RND efflux pump

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