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TitleStructure-Guided Control of siRNA Off-Target Effects.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 138, Page 8667-8669, Year 2016
Publish dateJun 16, 2016 (structure data deposition date)
AuthorsSuter, S.R. / Sheu-Gruttadauria, J. / Schirle, N.T. / Valenzuela, R. / Ball-Jones, A.A. / Onizuka, K. / MacRae, I.J. / Beal, P.A.
External linksJ. Am. Chem. Soc. / PubMed:27387838
MethodsX-ray diffraction
Resolution2.153 Å
Structure data

PDB-5ki6:
Human Argonaute-2 bound to a guide RNA with a nucleobase modification at position 1
Method: X-RAY DIFFRACTION / Resolution: 2.153 Å

Chemicals

ChemComp-IPH:
PHENOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/RNA / Argonaute / miRNA / RNAi / HYDROLASE-RNA complex

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