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TitleStructural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 138, Page 8694-8697, Year 2016
Publish dateMay 7, 2016 (structure data deposition date)
AuthorsSchirle, N.T. / Kinberger, G.A. / Murray, H.F. / Lima, W.F. / Prakash, T.P. / MacRae, I.J.
External linksJ. Am. Chem. Soc. / PubMed:27380263
MethodsX-ray diffraction
Resolution2.499 - 2.954 Å
Structure data

PDB-5js1:
Human Argonaute2 Bound to an siRNA
Method: X-RAY DIFFRACTION / Resolution: 2.499 Å

PDB-5js2:
Human Argonaute-2 Bound to a Modified siRNA
Method: X-RAY DIFFRACTION / Resolution: 2.954 Å

Chemicals

ChemComp-IPH:
PHENOL

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE/RNA / Argonaute / siRNA / RNAi / nuclease / HYDROLASE-RNA complex

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